Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation. [electronic resource]
Producer: 19940225Description: 1889-95 p. digitalISSN:- 0021-9258
- Adenosine Triphosphate -- pharmacology
- Amino Acid Sequence
- Animals
- Arachidonic Acid -- metabolism
- Base Sequence
- CHO Cells
- Calcium -- metabolism
- Calcium-Calmodulin-Dependent Protein Kinases -- metabolism
- Cholera Toxin -- pharmacology
- Clone Cells
- Cricetinae
- Cyclic AMP -- metabolism
- Cytoplasm -- enzymology
- Enzyme Activation
- GTP-Binding Proteins -- biosynthesis
- Gene Expression
- Kinetics
- Macromolecular Substances
- Molecular Sequence Data
- Molecular Weight
- Mutagenesis, Site-Directed
- Oligodeoxyribonucleotides
- Phospholipases A -- antagonists & inhibitors
- Phospholipases A2
- Phospholipids -- metabolism
- Protein Kinase C -- metabolism
- Signal Transduction
- Tetradecanoylphorbol Acetate -- pharmacology
- Thrombin -- pharmacology
- Transfection
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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