Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation.

Winitz, S

Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation. [electronic resource] - The Journal of biological chemistry Jan 1994 - 1889-95 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0021-9258


Adenosine Triphosphate--pharmacology
Amino Acid Sequence
Animals
Arachidonic Acid--metabolism
Base Sequence
CHO Cells
Calcium--metabolism
Calcium-Calmodulin-Dependent Protein Kinases--metabolism
Cholera Toxin--pharmacology
Clone Cells
Cricetinae
Cyclic AMP--metabolism
Cytoplasm--enzymology
Enzyme Activation
GTP-Binding Proteins--biosynthesis
Gene Expression
Kinetics
Macromolecular Substances
Molecular Sequence Data
Molecular Weight
Mutagenesis, Site-Directed
Oligodeoxyribonucleotides
Phospholipases A--antagonists & inhibitors
Phospholipases A2
Phospholipids--metabolism
Protein Kinase C--metabolism
Signal Transduction
Tetradecanoylphorbol Acetate--pharmacology
Thrombin--pharmacology
Transfection