Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo. [electronic resource]
Producer: 19931220Description: 24832-7 p. digitalISSN:- 0021-9258
- Administration, Oral
- Animals
- Anticholesteremic Agents -- pharmacology
- Cholesterol -- biosynthesis
- Coenzymes
- Cricetinae
- Diphosphonates -- administration & dosage
- Dolichols -- metabolism
- Farnesyl-Diphosphate Farnesyltransferase -- antagonists & inhibitors
- Humans
- Lovastatin -- pharmacology
- Male
- Mesocricetus
- Microsomes, Liver -- enzymology
- Rats
- Rats, Sprague-Dawley
- Squalene -- metabolism
- Ubiquinone -- analogs & derivatives
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Publication Type: Journal Article
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