Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo.

Ciosek, C P

Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo. [electronic resource] - The Journal of biological chemistry Nov 1993 - 24832-7 p. digital

Publication Type: Journal Article

0021-9258


Administration, Oral
Animals
Anticholesteremic Agents--pharmacology
Cholesterol--biosynthesis
Coenzymes
Cricetinae
Diphosphonates--administration & dosage
Dolichols--metabolism
Farnesyl-Diphosphate Farnesyltransferase--antagonists & inhibitors
Humans
Lovastatin--pharmacology
Male
Mesocricetus
Microsomes, Liver--enzymology
Rats
Rats, Sprague-Dawley
Squalene--metabolism
Ubiquinone--analogs & derivatives