Artificial duplication of the R67 dihydrofolate reductase gene to create protein asymmetry. Effects on protein activity and folding. [electronic resource]
Producer: 19931201Description: 22672-9 p. digitalISSN:- 0021-9258
- Amino Acid Sequence
- Base Sequence
- Calorimetry, Differential Scanning
- Circular Dichroism
- Cloning, Molecular
- Enzyme Stability
- Escherichia coli -- enzymology
- Genes, Bacterial
- Kinetics
- Macromolecular Substances
- Mathematics
- Models, Structural
- Molecular Sequence Data
- Multigene Family
- Protein Conformation
- Protein Denaturation
- Protein Folding
- Protein Structure, Secondary
- R Factors
- Recombinant Proteins -- chemistry
- Restriction Mapping
- Tetrahydrofolate Dehydrogenase -- chemistry
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Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
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