Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors. [electronic resource]
Producer: 19931020Description: 19943-8 p. digitalISSN:- 0021-9258
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- DNA
- Electrophoresis, Polyacrylamide Gel
- Enzyme Activation
- Factor Va -- antagonists & inhibitors
- Factor X -- metabolism
- Glutamates
- Glutamic Acid
- Glutamine
- Humans
- Kinetics
- Molecular Sequence Data
- Molecular Weight
- Mutagenesis, Site-Directed
- Oligodeoxyribonucleotides
- Oligonucleotides, Antisense
- Protein C -- biosynthesis
- Prothrombin -- metabolism
- Receptors, Cell Surface -- metabolism
- Receptors, Thrombin
- Recombinant Proteins -- biosynthesis
- Substrate Specificity
- Thrombin -- metabolism
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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