Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors.

Rezaie, A R

Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors. [electronic resource] - The Journal of biological chemistry Sep 1993 - 19943-8 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9258


Amino Acid Sequence
Animals
Base Sequence
Cattle
DNA
Electrophoresis, Polyacrylamide Gel
Enzyme Activation
Factor Va--antagonists & inhibitors
Factor X--metabolism
Glutamates
Glutamic Acid
Glutamine
Humans
Kinetics
Molecular Sequence Data
Molecular Weight
Mutagenesis, Site-Directed
Oligodeoxyribonucleotides
Oligonucleotides, Antisense
Protein C--biosynthesis
Prothrombin--metabolism
Receptors, Cell Surface--metabolism
Receptors, Thrombin
Recombinant Proteins--biosynthesis
Substrate Specificity
Thrombin--metabolism