Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease. [electronic resource]
Producer: 19941110Description: 9975-9 p. digitalISSN:- 0027-8424
- Animals
- Child, Preschool
- Exploratory Behavior
- Genetic Vectors
- Hexosaminidase A
- Humans
- Liver -- enzymology
- Lysosomes -- enzymology
- Mice
- Mice, Mutant Strains
- Microscopy, Electron
- Motor Activity
- Neurons -- pathology
- Parietal Lobe -- pathology
- Recombination, Genetic
- Restriction Mapping
- Tay-Sachs Disease -- enzymology
- beta-N-Acetylhexosaminidases -- deficiency
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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