Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease.

Yamanaka, S

Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Oct 1994 - 9975-9 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0027-8424

10.1073/pnas.91.21.9975 doi


Animals
Child, Preschool
Exploratory Behavior
Genetic Vectors
Hexosaminidase A
Humans
Liver--enzymology
Lysosomes--enzymology
Mice
Mice, Mutant Strains
Microscopy, Electron
Motor Activity
Neurons--pathology
Parietal Lobe--pathology
Recombination, Genetic
Restriction Mapping
Tay-Sachs Disease--enzymology
beta-N-Acetylhexosaminidases--deficiency