A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation. [electronic resource]
Producer: 19950130Description: 33116-22 p. digitalISSN:- 0021-9258
- Adaptor Proteins, Signal Transducing
- Animals
- CHO Cells
- Cricetinae
- GRB2 Adaptor Protein
- Guanosine Triphosphate -- metabolism
- Insulin Receptor Substrate Proteins
- Mitogen-Activated Protein Kinase 1
- Mutation
- Oncogene Protein p21(ras) -- metabolism
- Phosphoproteins -- metabolism
- Phosphorylation
- Protein Serine-Threonine Kinases -- metabolism
- Protein-Tyrosine Kinases -- metabolism
- Proteins -- metabolism
- Receptor, Insulin -- genetics
- Tyrosine -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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