A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.

Ouwens, D M

A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation. [electronic resource] - The Journal of biological chemistry Dec 1994 - 33116-22 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258


Adaptor Proteins, Signal Transducing
Animals
CHO Cells
Cricetinae
GRB2 Adaptor Protein
Guanosine Triphosphate--metabolism
Insulin Receptor Substrate Proteins
Mitogen-Activated Protein Kinase 1
Mutation
Oncogene Protein p21(ras)--metabolism
Phosphoproteins--metabolism
Phosphorylation
Protein Serine-Threonine Kinases--metabolism
Protein-Tyrosine Kinases--metabolism
Proteins--metabolism
Receptor, Insulin--genetics
Tyrosine--metabolism