Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line. [electronic resource]
Producer: 19950919Description: 391-8 p. digitalISSN:- 0006-2952
- Cell Division -- drug effects
- Cell-Free System
- Dose-Response Relationship, Drug
- Drug Resistance
- Folic Acid Antagonists -- pharmacology
- Glutamates -- pharmacology
- Guanine -- analogs & derivatives
- Humans
- Methotrexate -- pharmacology
- Pemetrexed
- Peptide Synthases -- antagonists & inhibitors
- Pteroylpolyglutamic Acids -- metabolism
- Quinazolines -- pharmacology
- Thiophenes -- pharmacology
- Thymidylate Synthase -- antagonists & inhibitors
- Time Factors
- Tumor Cells, Cultured -- drug effects
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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