Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line.
Lu, K
Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line. [electronic resource] - Biochemical pharmacology Jul 1995 - 391-8 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0006-2952
10.1016/0006-2952(95)00135-m doi
Cell Division--drug effects
Cell-Free System
Dose-Response Relationship, Drug
Drug Resistance
Folic Acid Antagonists--pharmacology
Glutamates--pharmacology
Guanine--analogs & derivatives
Humans
Methotrexate--pharmacology
Pemetrexed
Peptide Synthases--antagonists & inhibitors
Pteroylpolyglutamic Acids--metabolism
Quinazolines--pharmacology
Thiophenes--pharmacology
Thymidylate Synthase--antagonists & inhibitors
Time Factors
Tumor Cells, Cultured--drug effects
Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line. [electronic resource] - Biochemical pharmacology Jul 1995 - 391-8 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0006-2952
10.1016/0006-2952(95)00135-m doi
Cell Division--drug effects
Cell-Free System
Dose-Response Relationship, Drug
Drug Resistance
Folic Acid Antagonists--pharmacology
Glutamates--pharmacology
Guanine--analogs & derivatives
Humans
Methotrexate--pharmacology
Pemetrexed
Peptide Synthases--antagonists & inhibitors
Pteroylpolyglutamic Acids--metabolism
Quinazolines--pharmacology
Thiophenes--pharmacology
Thymidylate Synthase--antagonists & inhibitors
Time Factors
Tumor Cells, Cultured--drug effects