Inhibition of endothelial nitric oxide synthase by ebselen. Prevention by thiols suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase. [electronic resource]
Producer: 19940127Description: 1112-8 p. digitalISSN:- 0022-3565
- Amino Acid Oxidoreductases -- antagonists & inhibitors
- Animals
- Aorta, Thoracic -- drug effects
- Azoles -- antagonists & inhibitors
- Benzamides -- pharmacology
- Cattle
- Drug Interactions
- Endothelium, Vascular -- drug effects
- Enzyme Activation
- Female
- Glutathione Peroxidase -- metabolism
- In Vitro Techniques
- Isoindoles
- Male
- Muscle Relaxation -- drug effects
- Muscle, Smooth, Vascular -- drug effects
- Nitric Oxide Synthase
- Organoselenium Compounds -- antagonists & inhibitors
- Rabbits
- Rats
- Rats, Wistar
- Sulfhydryl Compounds -- pharmacology
- Swine
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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