Inhibition of endothelial nitric oxide synthase by ebselen. Prevention by thiols suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase.

Zembowicz, A

Inhibition of endothelial nitric oxide synthase by ebselen. Prevention by thiols suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase. [electronic resource] - The Journal of pharmacology and experimental therapeutics Dec 1993 - 1112-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3565


Amino Acid Oxidoreductases--antagonists & inhibitors
Animals
Aorta, Thoracic--drug effects
Azoles--antagonists & inhibitors
Benzamides--pharmacology
Cattle
Drug Interactions
Endothelium, Vascular--drug effects
Enzyme Activation
Female
Glutathione Peroxidase--metabolism
In Vitro Techniques
Isoindoles
Male
Muscle Relaxation--drug effects
Muscle, Smooth, Vascular--drug effects
Nitric Oxide Synthase
Organoselenium Compounds--antagonists & inhibitors
Rabbits
Rats
Rats, Wistar
Sulfhydryl Compounds--pharmacology
Swine