EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma. [electronic resource]
Producer: 20210401Description: 2442-2454.e5 p. digitalISSN:- 1523-1747
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Cell Line, Tumor
- Chromatin Immunoprecipitation Sequencing
- DNA Methylation -- immunology
- Datasets as Topic
- Down-Regulation
- Drug Resistance, Neoplasm -- genetics
- Enhancer of Zeste Homolog 2 Protein -- antagonists & inhibitors
- Female
- Gene Expression Regulation, Neoplastic -- immunology
- Gene Silencing -- immunology
- Humans
- Immune Checkpoint Inhibitors -- pharmacology
- Interferon-alpha -- genetics
- Interferon-gamma -- genetics
- Melanoma -- drug therapy
- Mice
- Mutation
- Neoplasm Invasiveness -- genetics
- RNA-Seq
- Skin -- immunology
- Skin Neoplasms -- drug therapy
- Tumor Suppressor Proteins -- genetics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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