EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma.

Tiffen, Jessamy

EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma. [electronic resource] - The Journal of investigative dermatology 12 2020 - 2442-2454.e5 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1523-1747

10.1016/j.jid.2020.02.042 doi


Animals
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Cell Line, Tumor
Chromatin Immunoprecipitation Sequencing
DNA Methylation--immunology
Datasets as Topic
Down-Regulation
Drug Resistance, Neoplasm--genetics
Enhancer of Zeste Homolog 2 Protein--antagonists & inhibitors
Female
Gene Expression Regulation, Neoplastic--immunology
Gene Silencing--immunology
Humans
Immune Checkpoint Inhibitors--pharmacology
Interferon-alpha--genetics
Interferon-gamma--genetics
Melanoma--drug therapy
Mice
Mutation
Neoplasm Invasiveness--genetics
RNA-Seq
Skin--immunology
Skin Neoplasms--drug therapy
Tumor Suppressor Proteins--genetics
Xenograft Model Antitumor Assays