PLAGL2-EGFR-HIF-1/2α Signaling Loop Promotes HCC Progression and Erlotinib Insensitivity. [electronic resource]
Producer: 20210809Description: 674-691 p. digitalISSN:- 1527-3350
- Adult
- Aged
- Animals
- Basic Helix-Loop-Helix Transcription Factors -- metabolism
- Carcinoma, Hepatocellular -- drug therapy
- Cell Line, Tumor
- Cell Movement -- genetics
- Cell Proliferation -- genetics
- DNA-Binding Proteins -- genetics
- Disease Progression
- Drug Resistance, Neoplasm -- genetics
- ErbB Receptors -- antagonists & inhibitors
- Erlotinib Hydrochloride -- pharmacology
- Feedback, Physiological
- Female
- Gene Expression Regulation, Neoplastic
- Gene Knockdown Techniques
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Kaplan-Meier Estimate
- Liver -- pathology
- Liver Neoplasms -- drug therapy
- Male
- Mice
- Middle Aged
- Neoplasm Invasiveness -- genetics
- RNA-Binding Proteins -- genetics
- RNA-Seq
- Signal Transduction -- genetics
- Transcription Factors -- genetics
- Tumor Hypoxia
- Up-Regulation
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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