PLAGL2-EGFR-HIF-1/2α Signaling Loop Promotes HCC Progression and Erlotinib Insensitivity.

Hu, Weiwei

PLAGL2-EGFR-HIF-1/2α Signaling Loop Promotes HCC Progression and Erlotinib Insensitivity. [electronic resource] - Hepatology (Baltimore, Md.) 02 2021 - 674-691 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1527-3350

10.1002/hep.31293 doi


Adult
Aged
Animals
Basic Helix-Loop-Helix Transcription Factors--metabolism
Carcinoma, Hepatocellular--drug therapy
Cell Line, Tumor
Cell Movement--genetics
Cell Proliferation--genetics
DNA-Binding Proteins--genetics
Disease Progression
Drug Resistance, Neoplasm--genetics
ErbB Receptors--antagonists & inhibitors
Erlotinib Hydrochloride--pharmacology
Feedback, Physiological
Female
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--metabolism
Kaplan-Meier Estimate
Liver--pathology
Liver Neoplasms--drug therapy
Male
Mice
Middle Aged
Neoplasm Invasiveness--genetics
RNA-Binding Proteins--genetics
RNA-Seq
Signal Transduction--genetics
Transcription Factors--genetics
Tumor Hypoxia
Up-Regulation
Xenograft Model Antitumor Assays