The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin. [electronic resource]
Producer: 20201214Description: eaax0069 p. digitalISSN:- 2375-2548
- Actins -- chemistry
- Alleles
- Amino Acid Substitution
- Binding Sites
- Cardiomyopathy, Hypertrophic -- genetics
- Genetic Predisposition to Disease
- Humans
- Models, Molecular
- Mutation
- Myocardial Contraction -- genetics
- Myosins -- chemistry
- Protein Binding
- Protein Conformation
- Structure-Activity Relationship
- Ventricular Myosins -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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