The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin.

Sarkar, Saswata S

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin. [electronic resource] - Science advances 04 2020 - eaax0069 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2375-2548

10.1126/sciadv.aax0069 doi


Actins--chemistry
Alleles
Amino Acid Substitution
Binding Sites
Cardiomyopathy, Hypertrophic--genetics
Genetic Predisposition to Disease
Humans
Models, Molecular
Mutation
Myocardial Contraction--genetics
Myosins--chemistry
Protein Binding
Protein Conformation
Structure-Activity Relationship
Ventricular Myosins--genetics