An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. [electronic resource]
Producer: 20200504ISSN:- 1946-6242
- Adenosine Monophosphate -- administration & dosage
- Alanine -- administration & dosage
- Animals
- Antibiotic Prophylaxis
- Antiviral Agents -- administration & dosage
- Betacoronavirus -- physiology
- COVID-19
- Cell Line
- Coronavirus Infections -- drug therapy
- Cytidine -- administration & dosage
- Disease Models, Animal
- Drug Resistance, Viral
- Humans
- Hydroxylamines
- Lung -- pathology
- Mice
- Mice, Inbred C57BL
- Middle East Respiratory Syndrome Coronavirus -- physiology
- Models, Molecular
- Mutation -- drug effects
- Pandemics
- Pneumonia, Viral -- drug therapy
- Primary Cell Culture
- RNA, Viral
- RNA-Dependent RNA Polymerase -- chemistry
- Random Allocation
- Respiratory System -- cytology
- Ribonucleosides -- administration & dosage
- SARS-CoV-2
- Virus Replication -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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