Iron protects childhood acute lymphoblastic leukemia cells from methotrexate cytotoxicity. [electronic resource]
Producer: 20210903Description: 3537-3550 p. digitalISSN:- 2045-7634
- Acetylcysteine -- pharmacology
- Bone Marrow -- metabolism
- Cell Line, Tumor
- Cell Survival
- Child
- Child, Preschool
- Deferasirox -- pharmacology
- Drug Resistance, Neoplasm -- drug effects
- Female
- Ferric Compounds -- pharmacology
- Free Radical Scavengers -- pharmacology
- Humans
- Infant
- Inhibitory Concentration 50
- Iron -- metabolism
- Iron Chelating Agents -- pharmacology
- Male
- Methotrexate -- pharmacology
- Multidrug Resistance-Associated Proteins -- genetics
- NF-E2-Related Factor 2 -- genetics
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Quaternary Ammonium Compounds -- pharmacology
- RNA, Messenger -- metabolism
- Reactive Oxygen Species
- Superoxide Dismutase -- genetics
- Transcriptome
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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