The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells. [electronic resource]
Producer: 20201020Description: 3055-3063 p. digitalISSN:- 1083-351X
- Amino Acid Transport System y+ -- metabolism
- Antioxidants -- metabolism
- Cell Line, Tumor
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- Down-Regulation
- Glutathione -- metabolism
- Glutathione Disulfide -- metabolism
- Humans
- NAD(P)H Dehydrogenase (Quinone) -- metabolism
- NF-E2-Related Factor 2 -- metabolism
- Phosphorylation
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Mas
- Proto-Oncogene Proteins p21(ras) -- antagonists & inhibitors
- RNA Interference
- RNA, Small Interfering -- metabolism
- Reactive Oxygen Species -- metabolism
- Signal Transduction
- Tumor Suppressor Protein p53 -- genetics
- ral GTP-Binding Proteins -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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