The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells.

Yang, Hua

The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells. [electronic resource] - The Journal of biological chemistry 03 2020 - 3055-3063 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1083-351X

10.1074/jbc.RA119.011930 doi


Amino Acid Transport System y+--metabolism
Antioxidants--metabolism
Cell Line, Tumor
Cyclin-Dependent Kinase Inhibitor p21--genetics
Down-Regulation
Glutathione--metabolism
Glutathione Disulfide--metabolism
Humans
NAD(P)H Dehydrogenase (Quinone)--metabolism
NF-E2-Related Factor 2--metabolism
Phosphorylation
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Mas
Proto-Oncogene Proteins p21(ras)--antagonists & inhibitors
RNA Interference
RNA, Small Interfering--metabolism
Reactive Oxygen Species--metabolism
Signal Transduction
Tumor Suppressor Protein p53--genetics
ral GTP-Binding Proteins--antagonists & inhibitors