The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer. [electronic resource]
Producer: 20201014Description: 1293-1303 p. digitalISSN:- 1538-7445
- Animals
- Atorvastatin -- pharmacology
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cholesterol -- biosynthesis
- Gene Knockdown Techniques
- Humans
- Hydroxymethylglutaryl CoA Reductases -- metabolism
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Lipid Metabolism -- drug effects
- Lipidomics
- Lung Neoplasms -- drug therapy
- MAP Kinase Kinase 5 -- genetics
- MAP Kinase Signaling System -- genetics
- Mevalonic Acid -- metabolism
- Mice
- Mitogen-Activated Protein Kinase 7 -- genetics
- RNA-Seq
- Small Cell Lung Carcinoma -- drug therapy
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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