The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer.

Cristea, Sandra

The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer. [electronic resource] - Cancer research 03 2020 - 1293-1303 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1538-7445

10.1158/0008-5472.CAN-19-1027 doi


Animals
Atorvastatin--pharmacology
Cell Line, Tumor
Cell Survival--drug effects
Cholesterol--biosynthesis
Gene Knockdown Techniques
Humans
Hydroxymethylglutaryl CoA Reductases--metabolism
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Lipid Metabolism--drug effects
Lipidomics
Lung Neoplasms--drug therapy
MAP Kinase Kinase 5--genetics
MAP Kinase Signaling System--genetics
Mevalonic Acid--metabolism
Mice
Mitogen-Activated Protein Kinase 7--genetics
RNA-Seq
Small Cell Lung Carcinoma--drug therapy
Xenograft Model Antitumor Assays