Nanoformulation of EPZ011989 Attenuates EZH2-c-Myb Epigenetic Interaction by Proteasomal Degradation in Acute Myeloid Leukemia. [electronic resource]
Producer: 20201211Description: 604-621 p. digitalISSN:- 1543-8392
- Animals
- Cell Survival -- drug effects
- Drug Compounding -- methods
- Drug Delivery Systems -- methods
- Enhancer of Zeste Homolog 2 Protein -- antagonists & inhibitors
- Epigenesis, Genetic -- drug effects
- Female
- Gene Expression Regulation, Neoplastic
- HEK293 Cells
- HL-60 Cells
- Humans
- Leukemia, Myeloid, Acute -- drug therapy
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Nanoparticles -- administration & dosage
- Proteasome Endopeptidase Complex -- metabolism
- Proteolysis -- drug effects
- Proto-Oncogene Proteins c-myb -- genetics
- Serum Albumin, Human -- chemistry
- Tissue Distribution
- Transfection
- U937 Cells
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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