Nanoformulation of EPZ011989 Attenuates EZH2-c-Myb Epigenetic Interaction by Proteasomal Degradation in Acute Myeloid Leukemia.
Kaundal, Babita
Nanoformulation of EPZ011989 Attenuates EZH2-c-Myb Epigenetic Interaction by Proteasomal Degradation in Acute Myeloid Leukemia. [electronic resource] - Molecular pharmaceutics 02 2020 - 604-621 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1543-8392
10.1021/acs.molpharmaceut.9b01071 doi
Animals
Cell Survival--drug effects
Drug Compounding--methods
Drug Delivery Systems--methods
Enhancer of Zeste Homolog 2 Protein--antagonists & inhibitors
Epigenesis, Genetic--drug effects
Female
Gene Expression Regulation, Neoplastic
HEK293 Cells
HL-60 Cells
Humans
Leukemia, Myeloid, Acute--drug therapy
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Nanoparticles--administration & dosage
Proteasome Endopeptidase Complex--metabolism
Proteolysis--drug effects
Proto-Oncogene Proteins c-myb--genetics
Serum Albumin, Human--chemistry
Tissue Distribution
Transfection
U937 Cells
Xenograft Model Antitumor Assays
Nanoformulation of EPZ011989 Attenuates EZH2-c-Myb Epigenetic Interaction by Proteasomal Degradation in Acute Myeloid Leukemia. [electronic resource] - Molecular pharmaceutics 02 2020 - 604-621 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1543-8392
10.1021/acs.molpharmaceut.9b01071 doi
Animals
Cell Survival--drug effects
Drug Compounding--methods
Drug Delivery Systems--methods
Enhancer of Zeste Homolog 2 Protein--antagonists & inhibitors
Epigenesis, Genetic--drug effects
Female
Gene Expression Regulation, Neoplastic
HEK293 Cells
HL-60 Cells
Humans
Leukemia, Myeloid, Acute--drug therapy
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Nanoparticles--administration & dosage
Proteasome Endopeptidase Complex--metabolism
Proteolysis--drug effects
Proto-Oncogene Proteins c-myb--genetics
Serum Albumin, Human--chemistry
Tissue Distribution
Transfection
U937 Cells
Xenograft Model Antitumor Assays