Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production. [electronic resource]
Producer: 20200909ISSN:- 1540-9538
- Animals
- Antibody Formation -- genetics
- Autoantibodies -- blood
- Autoantigens -- immunology
- Autoimmunity -- genetics
- Class I Phosphatidylinositol 3-Kinases -- blood
- Female
- Gain of Function Mutation
- Germinal Center -- immunology
- Humans
- Immune Tolerance -- immunology
- Immunoglobulin M -- blood
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Plasma Cells -- immunology
- Signal Transduction -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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