Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production.

Lau, Anthony

Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production. [electronic resource] - The Journal of experimental medicine 02 2020

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

1540-9538

10.1084/jem.20191336 doi


Animals
Antibody Formation--genetics
Autoantibodies--blood
Autoantigens--immunology
Autoimmunity--genetics
Class I Phosphatidylinositol 3-Kinases--blood
Female
Gain of Function Mutation
Germinal Center--immunology
Humans
Immune Tolerance--immunology
Immunoglobulin M--blood
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Plasma Cells--immunology
Signal Transduction--genetics