Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin. [electronic resource]
Producer: 20200430Description: 81-92 p. digitalISSN:- 2352-3964
- Adolescent
- Animals
- Carboplatin -- pharmacology
- Cell Line, Tumor
- Cell Survival -- drug effects
- Child
- Child, Preschool
- Cross-Linking Reagents -- pharmacology
- DNA Damage
- Disease Models, Animal
- Drug Resistance, Neoplasm -- genetics
- Fanconi Anemia Complementation Group D2 Protein -- genetics
- Female
- Glioma -- genetics
- Humans
- Male
- Mice
- Neoplasm Grading
- Pentacyclic Triterpenes
- Proteolysis -- drug effects
- Triterpenes -- pharmacology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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