Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin.

Metselaar, Dennis S

Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin. [electronic resource] - EBioMedicine Dec 2019 - 81-92 p. digital

Publication Type: Journal Article

2352-3964

10.1016/j.ebiom.2019.10.062 doi


Adolescent
Animals
Carboplatin--pharmacology
Cell Line, Tumor
Cell Survival--drug effects
Child
Child, Preschool
Cross-Linking Reagents--pharmacology
DNA Damage
Disease Models, Animal
Drug Resistance, Neoplasm--genetics
Fanconi Anemia Complementation Group D2 Protein--genetics
Female
Glioma--genetics
Humans
Male
Mice
Neoplasm Grading
Pentacyclic Triterpenes
Proteolysis--drug effects
Triterpenes--pharmacology
Xenograft Model Antitumor Assays