Oxidative Cyclization-Induced Activation of a Phosphoinositide 3-Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics. [electronic resource]
Producer: 20200922Description: 1933-1939 p. digitalISSN:- 1860-7187
- Antineoplastic Agents -- chemical synthesis
- Cell Line
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Cyclization
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Humans
- Microsomes, Liver -- chemistry
- Molecular Structure
- Oxidation-Reduction
- Phosphatidylinositol 3-Kinases -- metabolism
- Protein Kinase Inhibitors -- chemical synthesis
- Reactive Oxygen Species -- analysis
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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