Oxidative Cyclization-Induced Activation of a Phosphoinositide 3-Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics.
Zhu, Haizhou
Oxidative Cyclization-Induced Activation of a Phosphoinositide 3-Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics. [electronic resource] - ChemMedChem 11 2019 - 1933-1939 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
1860-7187
10.1002/cmdc.201900481 doi
Antineoplastic Agents--chemical synthesis
Cell Line
Cell Proliferation--drug effects
Cell Survival--drug effects
Cyclization
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Microsomes, Liver--chemistry
Molecular Structure
Oxidation-Reduction
Phosphatidylinositol 3-Kinases--metabolism
Protein Kinase Inhibitors--chemical synthesis
Reactive Oxygen Species--analysis
Structure-Activity Relationship
Oxidative Cyclization-Induced Activation of a Phosphoinositide 3-Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics. [electronic resource] - ChemMedChem 11 2019 - 1933-1939 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
1860-7187
10.1002/cmdc.201900481 doi
Antineoplastic Agents--chemical synthesis
Cell Line
Cell Proliferation--drug effects
Cell Survival--drug effects
Cyclization
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Microsomes, Liver--chemistry
Molecular Structure
Oxidation-Reduction
Phosphatidylinositol 3-Kinases--metabolism
Protein Kinase Inhibitors--chemical synthesis
Reactive Oxygen Species--analysis
Structure-Activity Relationship