The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer. [electronic resource]
Producer: 20200114Description: 4682 p. digitalISSN:- 2041-1723
- Animals
- Body Weight -- drug effects
- CD8-Positive T-Lymphocytes -- immunology
- Cachexia
- Carcinoma, Pancreatic Ductal -- genetics
- Cell Line, Tumor
- Eating -- drug effects
- Gene Expression
- Humans
- Imidazoles -- pharmacology
- Locomotion -- drug effects
- Mice
- Mice, Knockout
- Pancreatic Intraductal Neoplasms -- genetics
- Pancreatic Neoplasms -- genetics
- Sequence Analysis, RNA
- Survival Rate
- Toll-Like Receptor 7 -- agonists
- Toll-Like Receptor 8 -- agonists
- Tumor Burden
- Tumor Microenvironment -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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