The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer.
Michaelis, Katherine A
The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer. [electronic resource] - Nature communications 10 2019 - 4682 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2041-1723
10.1038/s41467-019-12657-w doi
Animals
Body Weight--drug effects
CD8-Positive T-Lymphocytes--immunology
Cachexia
Carcinoma, Pancreatic Ductal--genetics
Cell Line, Tumor
Eating--drug effects
Gene Expression
Humans
Imidazoles--pharmacology
Locomotion--drug effects
Mice
Mice, Knockout
Pancreatic Intraductal Neoplasms--genetics
Pancreatic Neoplasms--genetics
Sequence Analysis, RNA
Survival Rate
Toll-Like Receptor 7--agonists
Toll-Like Receptor 8--agonists
Tumor Burden
Tumor Microenvironment--drug effects
The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer. [electronic resource] - Nature communications 10 2019 - 4682 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2041-1723
10.1038/s41467-019-12657-w doi
Animals
Body Weight--drug effects
CD8-Positive T-Lymphocytes--immunology
Cachexia
Carcinoma, Pancreatic Ductal--genetics
Cell Line, Tumor
Eating--drug effects
Gene Expression
Humans
Imidazoles--pharmacology
Locomotion--drug effects
Mice
Mice, Knockout
Pancreatic Intraductal Neoplasms--genetics
Pancreatic Neoplasms--genetics
Sequence Analysis, RNA
Survival Rate
Toll-Like Receptor 7--agonists
Toll-Like Receptor 8--agonists
Tumor Burden
Tumor Microenvironment--drug effects