Inhibition by lipoxygenase products of TXA2-like responses of platelets and vascular smooth muscle. 14-Hydroxy from 22:6n-3 is more potent than 12-HETE. [electronic resource]
Producer: 19880510Description: 1275-80 p. digitalISSN:- 0006-2952
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
- Animals
- Blood Platelets -- drug effects
- Docosahexaenoic Acids -- pharmacology
- Fatty Acids, Unsaturated -- pharmacology
- Female
- Guinea Pigs
- Humans
- Hydroxyeicosatetraenoic Acids -- pharmacology
- In Vitro Techniques
- Male
- Muscle, Smooth, Vascular -- drug effects
- Platelet Aggregation -- drug effects
- Rabbits
- Receptors, Prostaglandin -- drug effects
- Receptors, Thromboxane
- Structure-Activity Relationship
- Thromboxane A2 -- antagonists & inhibitors
- Vasoconstriction
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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