Inhibition by lipoxygenase products of TXA2-like responses of platelets and vascular smooth muscle. 14-Hydroxy from 22:6n-3 is more potent than 12-HETE.

Croset, M

Inhibition by lipoxygenase products of TXA2-like responses of platelets and vascular smooth muscle. 14-Hydroxy from 22:6n-3 is more potent than 12-HETE. [electronic resource] - Biochemical pharmacology Apr 1988 - 1275-80 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-2952

10.1016/0006-2952(88)90782-4 doi


12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Animals
Blood Platelets--drug effects
Docosahexaenoic Acids--pharmacology
Fatty Acids, Unsaturated--pharmacology
Female
Guinea Pigs
Humans
Hydroxyeicosatetraenoic Acids--pharmacology
In Vitro Techniques
Male
Muscle, Smooth, Vascular--drug effects
Platelet Aggregation--drug effects
Rabbits
Receptors, Prostaglandin--drug effects
Receptors, Thromboxane
Structure-Activity Relationship
Thromboxane A2--antagonists & inhibitors
Vasoconstriction