Napabucasin (BBI608) eliminate AML cells in vitro and in vivo via inhibition of Stat3 pathway and induction of DNA damage. [electronic resource]
Producer: 20191220Description: 252-261 p. digitalISSN:- 1879-0712
- Adolescent
- Adult
- Aged
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Benzofurans -- pharmacology
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- DNA Damage
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm -- drug effects
- Female
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Leukemia, Myeloid, Acute -- drug therapy
- Male
- Membrane Potential, Mitochondrial -- drug effects
- Mice
- Middle Aged
- Naphthoquinones -- pharmacology
- Resting Phase, Cell Cycle -- drug effects
- STAT3 Transcription Factor -- metabolism
- Time Factors
- Xenograft Model Antitumor Assays
- Young Adult
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Publication Type: Journal Article
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