Napabucasin (BBI608) eliminate AML cells in vitro and in vivo via inhibition of Stat3 pathway and induction of DNA damage.
Bi, Silei
Napabucasin (BBI608) eliminate AML cells in vitro and in vivo via inhibition of Stat3 pathway and induction of DNA damage. [electronic resource] - European journal of pharmacology Jul 2019 - 252-261 p. digital
Publication Type: Journal Article
1879-0712
10.1016/j.ejphar.2019.05.020 doi
Adolescent
Adult
Aged
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Benzofurans--pharmacology
Cell Line, Tumor
Cell Proliferation--drug effects
DNA Damage
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm--drug effects
Female
G1 Phase Cell Cycle Checkpoints--drug effects
Humans
Leukemia, Myeloid, Acute--drug therapy
Male
Membrane Potential, Mitochondrial--drug effects
Mice
Middle Aged
Naphthoquinones--pharmacology
Resting Phase, Cell Cycle--drug effects
STAT3 Transcription Factor--metabolism
Time Factors
Xenograft Model Antitumor Assays
Young Adult
Napabucasin (BBI608) eliminate AML cells in vitro and in vivo via inhibition of Stat3 pathway and induction of DNA damage. [electronic resource] - European journal of pharmacology Jul 2019 - 252-261 p. digital
Publication Type: Journal Article
1879-0712
10.1016/j.ejphar.2019.05.020 doi
Adolescent
Adult
Aged
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Benzofurans--pharmacology
Cell Line, Tumor
Cell Proliferation--drug effects
DNA Damage
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm--drug effects
Female
G1 Phase Cell Cycle Checkpoints--drug effects
Humans
Leukemia, Myeloid, Acute--drug therapy
Male
Membrane Potential, Mitochondrial--drug effects
Mice
Middle Aged
Naphthoquinones--pharmacology
Resting Phase, Cell Cycle--drug effects
STAT3 Transcription Factor--metabolism
Time Factors
Xenograft Model Antitumor Assays
Young Adult