Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment. [electronic resource]
Producer: 20200824Description: 890-909 p. digitalISSN:- 2159-8290
- Animals
- Antineoplastic Agents -- metabolism
- Apoptosis -- drug effects
- Bridged Bicyclo Compounds, Heterocyclic -- pharmacology
- Cell Line, Tumor
- Clustered Regularly Interspaced Short Palindromic Repeats
- Drug Resistance, Neoplasm
- Endopeptidase Clp -- antagonists & inhibitors
- GTP Phosphohydrolases -- biosynthesis
- HEK293 Cells
- HeLa Cells
- Humans
- K562 Cells
- Leukemia, Myeloid, Acute -- drug therapy
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Mitochondria -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Sulfonamides -- pharmacology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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