Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment.
Chen, Xufeng
Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment. [electronic resource] - Cancer discovery 07 2019 - 890-909 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
2159-8290
10.1158/2159-8290.CD-19-0117 doi
Animals
Antineoplastic Agents--metabolism
Apoptosis--drug effects
Bridged Bicyclo Compounds, Heterocyclic--pharmacology
Cell Line, Tumor
Clustered Regularly Interspaced Short Palindromic Repeats
Drug Resistance, Neoplasm
Endopeptidase Clp--antagonists & inhibitors
GTP Phosphohydrolases--biosynthesis
HEK293 Cells
HeLa Cells
Humans
K562 Cells
Leukemia, Myeloid, Acute--drug therapy
Mice
Mice, Inbred NOD
Mice, SCID
Mitochondria--drug effects
Proto-Oncogene Proteins c-bcl-2--antagonists & inhibitors
Sulfonamides--pharmacology
Xenograft Model Antitumor Assays
Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment. [electronic resource] - Cancer discovery 07 2019 - 890-909 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
2159-8290
10.1158/2159-8290.CD-19-0117 doi
Animals
Antineoplastic Agents--metabolism
Apoptosis--drug effects
Bridged Bicyclo Compounds, Heterocyclic--pharmacology
Cell Line, Tumor
Clustered Regularly Interspaced Short Palindromic Repeats
Drug Resistance, Neoplasm
Endopeptidase Clp--antagonists & inhibitors
GTP Phosphohydrolases--biosynthesis
HEK293 Cells
HeLa Cells
Humans
K562 Cells
Leukemia, Myeloid, Acute--drug therapy
Mice
Mice, Inbred NOD
Mice, SCID
Mitochondria--drug effects
Proto-Oncogene Proteins c-bcl-2--antagonists & inhibitors
Sulfonamides--pharmacology
Xenograft Model Antitumor Assays