Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent. [electronic resource]
Producer: 20200505Description: 404-413 p. digitalISSN:- 1573-675X
- Apoptosis -- drug effects
- Bortezomib -- pharmacology
- Caspase Inhibitors -- pharmacology
- Caspases -- metabolism
- Cell Line, Tumor
- Cell Survival -- drug effects
- DNA Damage
- Deoxyribonucleases -- deficiency
- Depsipeptides -- pharmacology
- Histone Deacetylase Inhibitors -- pharmacology
- Humans
- Hypoxanthine Phosphoribosyltransferase -- genetics
- Mitochondria -- drug effects
- Mutagenesis
- Mutation -- drug effects
- Poly-ADP-Ribose Binding Proteins -- deficiency
- Proteasome Inhibitors -- pharmacology
- Signal Transduction -- drug effects
- Vorinostat -- pharmacology
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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