Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent.
Miles, Mark A
Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent. [electronic resource] - Apoptosis : an international journal on programmed cell death 06 2019 - 404-413 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1573-675X
10.1007/s10495-019-01543-x doi
Apoptosis--drug effects
Bortezomib--pharmacology
Caspase Inhibitors--pharmacology
Caspases--metabolism
Cell Line, Tumor
Cell Survival--drug effects
DNA Damage
Deoxyribonucleases--deficiency
Depsipeptides--pharmacology
Histone Deacetylase Inhibitors--pharmacology
Humans
Hypoxanthine Phosphoribosyltransferase--genetics
Mitochondria--drug effects
Mutagenesis
Mutation--drug effects
Poly-ADP-Ribose Binding Proteins--deficiency
Proteasome Inhibitors--pharmacology
Signal Transduction--drug effects
Vorinostat--pharmacology
Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent. [electronic resource] - Apoptosis : an international journal on programmed cell death 06 2019 - 404-413 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1573-675X
10.1007/s10495-019-01543-x doi
Apoptosis--drug effects
Bortezomib--pharmacology
Caspase Inhibitors--pharmacology
Caspases--metabolism
Cell Line, Tumor
Cell Survival--drug effects
DNA Damage
Deoxyribonucleases--deficiency
Depsipeptides--pharmacology
Histone Deacetylase Inhibitors--pharmacology
Humans
Hypoxanthine Phosphoribosyltransferase--genetics
Mitochondria--drug effects
Mutagenesis
Mutation--drug effects
Poly-ADP-Ribose Binding Proteins--deficiency
Proteasome Inhibitors--pharmacology
Signal Transduction--drug effects
Vorinostat--pharmacology