The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition. [electronic resource]
Producer: 20200214Description: 5457-5468 p. digitalISSN:- 1476-5594
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Antimalarials -- pharmacology
- Apoptosis -- drug effects
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Chloroquine -- pharmacology
- DNA Damage
- Enzyme Inhibitors -- pharmacology
- Humans
- Ligands
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- metabolism
- Reactive Oxygen Species -- metabolism
- Receptor, Notch1 -- metabolism
- Signal Transduction -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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