The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition.
Hounjet, Judith
The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition. [electronic resource] - Oncogene 07 2019 - 5457-5468 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5594
10.1038/s41388-019-0802-x doi
Amyloid Precursor Protein Secretases--antagonists & inhibitors
Antimalarials--pharmacology
Apoptosis--drug effects
Cell Cycle--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Chloroquine--pharmacology
DNA Damage
Enzyme Inhibitors--pharmacology
Humans
Ligands
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma--metabolism
Reactive Oxygen Species--metabolism
Receptor, Notch1--metabolism
Signal Transduction--drug effects
The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition. [electronic resource] - Oncogene 07 2019 - 5457-5468 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5594
10.1038/s41388-019-0802-x doi
Amyloid Precursor Protein Secretases--antagonists & inhibitors
Antimalarials--pharmacology
Apoptosis--drug effects
Cell Cycle--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Chloroquine--pharmacology
DNA Damage
Enzyme Inhibitors--pharmacology
Humans
Ligands
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma--metabolism
Reactive Oxygen Species--metabolism
Receptor, Notch1--metabolism
Signal Transduction--drug effects