5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma. [electronic resource]
Producer: 20200622Description: 4350-4369 p. digitalISSN:- 1520-4804
- Animals
- Carboxylic Acids -- chemical synthesis
- Connective Tissue Growth Factor -- metabolism
- Enzyme Inhibitors -- chemical synthesis
- Female
- Fibrosis -- drug therapy
- Mice, Inbred C57BL
- Microsomes, Liver -- drug effects
- Molecular Structure
- Oxadiazoles -- chemical synthesis
- Scleroderma, Systemic -- drug therapy
- Serum Response Factor -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Skin -- pathology
- Structure-Activity Relationship
- Trans-Activators -- antagonists & inhibitors
- Transcription, Genetic -- drug effects
- rho GTP-Binding Proteins -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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