5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma.

Kahl, Dylan J

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma. [electronic resource] - Journal of medicinal chemistry 05 2019 - 4350-4369 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1520-4804

10.1021/acs.jmedchem.8b01772 doi


Animals
Carboxylic Acids--chemical synthesis
Connective Tissue Growth Factor--metabolism
Enzyme Inhibitors--chemical synthesis
Female
Fibrosis--drug therapy
Mice, Inbred C57BL
Microsomes, Liver--drug effects
Molecular Structure
Oxadiazoles--chemical synthesis
Scleroderma, Systemic--drug therapy
Serum Response Factor--antagonists & inhibitors
Signal Transduction--drug effects
Skin--pathology
Structure-Activity Relationship
Trans-Activators--antagonists & inhibitors
Transcription, Genetic--drug effects
rho GTP-Binding Proteins--antagonists & inhibitors