The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies. [electronic resource]
Producer: 20200203Description: 2403-2415 p. digitalISSN:- 1476-5551
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Differentiation -- drug effects
- Cell Line, Tumor
- Dihydroorotate Dehydrogenase
- Enzyme Inhibitors -- pharmacology
- Female
- HL-60 Cells
- Humans
- Leukemia, Myeloid, Acute -- drug therapy
- Leukemia, Promyelocytic, Acute -- drug therapy
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Oxidoreductases Acting on CH-CH Group Donors -- antagonists & inhibitors
- Pyrimidines -- metabolism
- THP-1 Cells
- Translocation, Genetic -- drug effects
No physical items for this record
Publication Type: Journal Article
There are no comments on this title.
Log in to your account to post a comment.